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GPCR signaling-related publications

33. Du Y, Duc NM, Rasmussen SGF, Hilger D, Kubiak X, Wang L, Bohon J, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee JM, Chance MR, Lodowski DT*, Kobilka BK*, Chung KY*. Assembly of a GPCR-G protein complex. Cell. 2019:177(5):1232-1242.e11. (*Corresponding authors)

32. Park JY, Qu C, Li R, Yang F, Tian Z, Shen Y, Cai B, Yun Y, Sun J*, Chung KY*. Structural mechanism of the arrestin-3/JNK3 interaction. Structure. Accepted. (*Corresponding authors)

31. Yang H-S, Sun N, Zhao X, Kim HR, Park H-J, Kim K-M, Chung KY*. Role of helix 8 in dopamine receptor signaling. Biomolecules & Therapeutics. Accepted. (*Corresponding author)

30. Ki AY, Park JY, Chung KY*. Conformational changes of JNK3 splice variants upon ATP binding. Biodesign. 2019:7(1):1-5. (*Corresponding author)

29. Bang I, Kim HR, Beaven AH, Kima J, Ko SB, Lee GR, Lee H, Im W, Seok C, Chung KY*, Choi H-J*. Biophysical and functional characterization of Norrin signaling through Frizzled4. Proceedings of the National Academy of Science USA. 2018:115(35):8787-8792. (*Corresponding author)

28. Liu H, Kim HR, Deepak RNVK, Wan L, Chung KY, Fan H, Wei Z, and Zhang C. Orthosteric and allosteric action of the C5a receptor antagonists. Nature Structural and Molecular Biology. 2018:25(6):472-481.

27. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, and Sun JP. Gq activity- and beta-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. 2018:7:e33432.

26. Kim HR, Duc NM, and Chung KY*. Comprehensive analysis of non-synonymous natural variants of G protein-coupled receptors. Biomolecules & Therapeutics. 2018:26(2):101-108. (*Corresponding author)

25. Park JY, Kim HR, and Chung KY*. Chapter 9. Localization of Conformational Dynamics of Arrestins by HDX-MS. The structural Basis of Arrestin Functions. (ISBN: 978-3-319-57552-0 (Print) 978-3-319-57553-7 (Online)) Invited book chapter (*Corresponding author)

24. Komolove KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror R, Chung KY, Kobilka BK, and Benovic JL. Structural and functional analysis of b2-adrenergic receptor complex with GRK5. Cell. 2017:169(3):407-421.

23. Park JY, Yun Y, and Chung KY*. Conformations of JNK3α splice variants analyzed by hydrogen/deuterium exchange mass spectrometry. Journal of Structural Biology. 2017:197(3):271-278. (*Corresponding author)

22. Duc NM, Kim HR, and Chung KY*. Recent progress in understanding the conformational mechanism of heterotrimeric G protein activation. Biomolecules & Therapeutics. 2017:25(1):4-11. (*Corresponding author)

21. Kim MH, Kim YJ, Kim HR, Chung KY*, and Kim MK*. Computational simulation of the activation cycle of Gα subunit in the G protein cycle using an elastic network model. Plos One. 2016:11(8):e0159528. (*Corresponding author)

20. Park JY, Lee SY, Kim HR, Seo MD, and Chung KY*. Structural mechanism of GPCR-arrestin interaction: recent breakthroughs. Archives of Pharmacal Research. 2016:39(3):293-301. (*Corresponding author)

19. Lee SY, Yun Y, Kim HR, and Chung KY*. Conformational analysis of β-Arrestin2 pre-activated mutant p44 by hydrogen/deuterium exchange mass spectrometry. Biodesign. 2015:3(4):162-167. (*Corresponding author)

18. Kim DK, Yun Y, Kim HR, Seo MD, and Chung KY*.  Different Conformational Dynamics of Various Active States of -Arrestin1 Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of Structural Biology. 2015:190(2):250-9. (*Corresponding author)

17. Duc NM, Kim HR, and Chung KY*. Structural mechanism of G protein activation by G protein-coupled receptor. European Journal of Pharmacology. 2015:763(Pt B):214-222. (*Corresponding author) (Invited review article)

16. Duc NM, Du Y, Thorsen TS, Lee SY, Zhang C, Kato H, Kobilka BK*, and Chung KY*. Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 2015:26(5):808-17. (*Corresponding author)

15. Li S, Lee SY, and Chung KY*. Conformational Analysis of G Protein-Coupled Receptor Signaling by Hydrogen/deuterium Exchange Mass Spectrometry. Methods in Enzymology. 2015:557:261-78. (*Corresponding author)

14. Yun Y. Kim DK, Kim KM, Seo MD, and Chung KY*. Different Conformational Dynamics of beta-Arrestin1 and beta-Arrestin2 Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry. Biochemical and Biophysical Research Communications. 2015:457(1):50-7 (*Corresponding author)

13. Ko IY, Kim DK, and Chung KY*. Structural Analysis of Muscarinic Acetylcholine Receptor Type 1 Intracellular Loop 3 by Hydrogen/Deuterium Exchange Mass Spectrometry. Protein & Peptide Letters. 2015:22(1):94-100. (*Corresponding author)

12. Chung KY*. Structural Aspects of GPCR-G Protein Coupling. Toxicological Research. 2013(29):149-55. (Reveiw article) (*Corresponding author)

11. Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Shaw DE, Kobilka BK,  and Prosser RS. The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor. Journal of the American Chemical Society. 2013:135(25):9465-74.

10. Chung KY*, Day PW, Vélez-Ruiz G, Sunahara RK, and Kobilka BK*. Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach. Plos One. 2013:8(1):e54942. (*Corresponding author)

9. Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, and Prosser RS. The role of detergents on conformational exchange of a G protein-coulpled receptor. Journal of Biological Chemistry. 2012:287(43):36305-11. (Faculty of 1000 Recommended)

8. Kang M, Walker JW, and Chung KY*. Endothelin receptor overexpression alters diastolic function in cultured rat ventricular myocytes. Biomolecules and Therapeutics. 2012:20(4):386-392. (*Corresponding author)

7. Kang M and Chung KY*. PKC-epsilon mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes. Biochemical and Biophysical Research Communications. 2012:423(3):600-5. (*Corresponding author)

6. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL Jr, and Sunahara RK. Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature. 2011:477(7366):611-5. (2012 Nobel Chemistry)

5. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, and Kobilka BK. Crystal structure of the beta2 adrenergic receptor-Gs protein complex. Nature. 2011:477(7366):549-55. (2012 Nobel Chemistry)

4. Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL Jr, Steyaert J, Kobilka BK, Sunahara RK, and Skiniotis G. Structural flexibility of the G{alpha}s {alpha}-helical domain in the {beta}2-adrenoceptor Gs complex. Proceedings of the National Academy of Science USA. 2011:108(38):16086-91.

3. Chung KY, Kang M and Walker JW. Contractile regulation via ETA requires intact T-tubules in adult rat ventricular myocytes. American Journal of Physiology. 2008:294(5):H2391-9.

2. Kang M, Chung KY and Walker JW. G-protein coupled receptor signaling in myocardium: not for the faint of heart. Physiology (Bethesda). 2007:22:174-84.

1. Chung KY and Walker JW. Interaction and inhibitory cross-talk between endothelin and ErbB receptors in the adult heart. Molecular Pharmacology. 2007:71(6):1494-502.


Other protein structure-related publications

12. Park BB, Choi JW, Park Y, Choi D, Paek J, Kim HJ, Son S-Y, Mushtaq AU, Shin H, Kim SH, Zhou Y, Lim TH, Park JY, Baek J-Y, Kim K, Kwon H, Son SH, Chung KY, Jeong H-J, Kim H-M, Jung WY, Lee K, Lee K, Byun Y, Jeon YH. Structure-activity relationships of Baicalein and its analogs as novel TSLP inhibitors. Scientific Reports. Accepted.

11. Jang S, Kang C, Yang H-S, Jung T, Hebert H, Chung KY, Hohng S, and Song J-J. Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase. Genes & Development. 2019:33(11-22):620-625.

10. Giladi M, Lee SY, Refaeli B, Hiler R, Chung KY*, Khananshvili D*. Structure-dynamic and functional relationships in a Li+-transporting sodium-calcium exchanger mutant. BBA-Bioenergetics. 2019:1860(3):189-200. (*Corresponding author)

9. Han SS, Min MK, Lee SY, Lim CW, Bhatnagar N, Lee Y, Shin D, Chung KY, Lee SC, Kim BG, and Lee S. Modulation of ABA Signaling by Altering VxGΦL Motif of PP2Cs in Oryza sativa. Molecular Plant. 2017:10(9):1190-1205.

8. Giladi M, Lee SY, Ariely Y, Teldan Y, Granit R, Strulevich R, Haitin Y, Chung KY*, and Khananshvili D*. Structure-based dynamic diversity in regulatory domains of sodium-calcium exchanger (NCX) isoforms. Scientific Reports. 2017:7:993. (*Corresponding author)

7. Lee SY, Yoo HS, Choi HS, Chung KY*, and Seo MD*. Structural and dynamic insights into the subtype-specific IP3 binding mechanism of IP3 receptor. Biochemical Journal. 2016:473(20):3533-3543. (*Corresponding author)

6. Lee SY, Giladi M, Bohbot H, Hiller R, Chung KY*, and Khananshvili D*. Structure-dynamic basis of splicing dependent regulation in tissue-specific variants of the sodium-calcium exchanger (NCX1). FASEB Journal. 2016:30(3):1356-1366. (*Corresponding author)

5. Lee KY, Choi HS, Choi HS, Chung KY, Lee BJ, Maeng HJ, and Seo MD. Quercetin directly interacts with vitamin D (VDR): Structural implication of VDR activation by quercetin. Biomolecules and Therapeutics. 2016:24(2):191-198.

4. Lee YS, Yoon WS, Chung I, Chung KY, Won HS, and Seo MD. Backbone NMR assignments of an uncharacterized protein, SF1002 from Shigella flexneri 5a M90T. Journal of the Korean Magnetic Resonance Society. 2015:19:36-41.

3. Kim HN, Seok SH, Chung KY, Won HS, Son WS, and Seo MD. Expression, purification and structural characterization of the type 1-specific ATP binding site of IP3 receptor (IP3R1-ATPA). Process Biochemistry. 2015:50(10):1600-1606.

2. Giladi M, Lee SY, Hiller R, Chung KY* and Khananshvili D*. Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na+/Ca2+ Exchange (NCX) Proteins. Biochemical Journal. 2015:465(3):489-501 (* Corresponding author)

1. Park JY, Duc NM, Kim DK, Lee SY, Li S, Seo MD, Woods VL Jr, and Chung KY*. Different Conformational Dynamics of PDZ1 and PDZ2 in Full-length EBP50 Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry. Biochemistry and Cell Biology. 2015:93(4):290-7. (*Corresponding author)



6. Lee M, Park H, Jeon SW, Bang J, Chung KY, Choi DW, Kim E, and Lim KM. Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12. Archives of Dermatological Research. 2015:307(3):249-57.

5. Kim K, Bae ON, Lim KM, Noh JY, Kang S, Chung KY, and Chung JH. Novel anti-platelet activity of protocatechuic acid through inhibition of high shear stress-induced aggregation. Journal of Pharmacology and Experimental Therapeutics. 2012:343(3):704-11.

4. Lim KM, Kim JS, Bae ON, Noh JY, Chung SM, Chung KY, and Chung JH. Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets. Toxicology. 2008:247(2-3):154-60.

3. Chung KY, Lim KM, Chung SM, Lee MY, Noh JY, Bae ON and Chung JH. Shear stress-induced pH increase in plasma is mediated by a decrease in P(CO(2)): the increase in pH enhances shear stress-induced P-selectin expression in platelets. Platelets. 2006:17(3):127-33.

2. Chung KY, Lee SJ, Chung SM, Lee MY, Bae ON and Chung JH. Generation of free radical by interaction of iron with thiols in human plasma and its possible significance. Thrombosis Research. 2005:116(2):157-64.

1. Bae ON, Lee JY, Chung GY, Chung SM, Lee MY, Yun YP, Kim YC, Moon CK and Chung JH. Enhanced menadione cytotoxicity in platelets isolated from streptozotocin-induced diabetic rats. Thrombosis Research. 2003:111(3):179-83.


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